LXY3

SKU: orb3022991

Description

LXY3 (LXY2) is a VLA-3 blocking peptide that inhibits the interaction of neutrophil surface integrin α3β1 (VLA-3) with laminin in the basement membrane, thereby preventing neutrophil migration across the tumor vascular basement membrane barrier. LXY3 is employed to block the neutrophil-mediated release of nanoparticles from the perivascular pool into the tumor stroma and is frequently used for targeted imaging in breast cancer.

Research Area

Signal Transduction

Key Properties

• Target: Integrin
• CAS Number: 1095009-44-1
• MW: 885.88
• Formula: C₃₂H₄₃N₁₁O₁₅S₂
• SMILES: O=C1[C@]2(N(C[C@H](O)C2)C(=O)CNC(=O)[C@H](CC3=CC(N(=O)=O)=C(O)C=C3)NC(=O)CNC(=O)[C@@H](CC(O)=O)NC(=O)[C@H](N)CSSC[C@H](C(N)=O)NC(=O)[C@H](CC(N)=O)N1)[H]

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Integrin