LSN2839567

SKU: orb1710508

Description

LSN2839567 (Abemaciclib metabolite M2) is the active metabolite of the CDK4/6 inhibitor Abemaciclib, also inhibiting CDK9. It demonstrates concentration-dependent inhibition of cell growth and cycle progression in vitro, making it a valuable research tool for studying cancers such as breast and lung cancer.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 1231930-57-6
• MW: 478.54
• Purity: 99.14% (May vary between batches)
• Formula: C₂₅H₂₈F₂N₈
• SMILES: CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc(CN3CCNCC3)cn2)ncc1F
• Target: Drug Metabolite,CDK
• Solubility: DMSO:1 mg/mL (2.09 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.09 mM)

Bioactivity

• Target IC50:
  CDK4:1-3 nM|CDK6:1-3 nM
• In Vivo:
  Abemaciclib metabolite M2 is a plasma metabolite of Abemaciclib with anticancer activity.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CDK9, CDK6, CDK4, Abemaciclib metabolite M2, Abemaciclib metabolite M-2, Abemaciclib Metabolites M2

Compound Identifiers

PubChem CID

59376686