LSD1/HDAC-IN-3

SKU: orb3173294

Description

LSD1/HDAC-IN-3 is an inhibitor targeting class I HDACs and LSD1. It effectively inhibits HDAC1, HDAC2, HDAC3, and LSD1 with IC50 values of 1702 nM, 842 nM, 358 nM, and 1074 nM, respectively. Demonstrating antioxidant properties, it increases acetylation and methylation of histone H3 in H2O2-treated ARPE-19 and 661W retinal cells. In the rd10 mouse model of retinitis pigmentosa, LSD1/HDAC-IN-3 enhances photoreceptor survival. It is applicable for studying hereditary retinal diseases such as retinitis pigmentosa (RP).

Key Properties

• Target: Histone Demethylase,HDAC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Histone Demethylase,HDAC