LpxH-IN-AZ1

SKU: orb1709246

Description

LpxH-IN-AZ1 is a potent sulfonylpiperazine inhibitor of the bacterial enzyme LpxH, a UDP-2,3-diacylglucosamine pyrophosphate hydrolase. It demonstrates antimicrobial activity, particularly against Klebsiella pneumoniae with an IC50 of 0.36 μM, making it a valuable tool for studying lipopolysaccharide biosynthesis in Gram-negative pathogens.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 901260-40-0
• MW: 453.48
• Purity: 99.84%
• Formula: C₂₁H₂₂F₃N₃O₃S
• SMILES: C(C)(=O)N1C=2C(=CC(S(=O)(=O)N3CCN(CC3)C4=CC(C(F)(F)F)=CC=C4)=CC2)CC1
• Target: Antibacterial
• Solubility: DMSO:4.54 mg/mL (10.01 mM)

Bioactivity

• Target IC50:
  LpxH (E. coli):0.14 μM|LpxH (Klebsiella pneumoniae):0.36 μM
• In Vitro:
  LpxH-IN-AZ1 (1 μM) inhibits K. pneumoniae LpxH activity by 75% and E. coli LpxH activity by 83% when 100 μM UDPDAGn is present. Additionally, it exhibits IC50 values of 0.36 μM for K. pneumoniae LpxH and 0.14 μM for E. coli LpxH.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LpxH IN AZ1, LpxHINAZ1, LpxH-IN-AZ1, LpxH-IN-AZ-1, Bacterial

Compound Identifiers

PubChem CID

16002750