Lotilaner

SKU: orb1308118

Description

Lotilaner

Research Area

Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1369852-71-0
• MW: 596.76
• Purity: 99.32% (May vary between batches)
• Formula: C₂₀H₁₄Cl₃F₆N₃O₃S
• SMILES: Cc1cc(sc1C(=O)NCC(=O)NCC(F)(F)F)C1=NO[C@@](C1)(c1cc(Cl)c(Cl)c(Cl)c1)C(F)(F)F
• Target: GABA Receptor,Parasite
• Solubility: DMSO:≥ 150 mg/mL (251.36 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.35 mM)

Bioactivity

• Target IC50:
  GABA:23.84 nM(DmS)|GABA:36.79 nM(Rm)|GABA:38.25 nM(DmR2)|GABA:52.40 nM(Ls-GABA1)
• In Vitro:
  Lotilaner displays IC50s of 38.25 ± 3.75, 52.40 ± 4.54, 36.79 ± 4.39 nM for Drosophila melanogaster dieldrin/fipronil-resistant forms (DmR2), Lepeophtheirus salmonis (Ls) and Rhipicephalus microplus (Rm) GABACl receptors, respectively.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Rm-GABA, γ-Aminobutyric acid Receptor, DmR2-GABA, DmS-GABA, Gamma-aminobutyric acid Receptor, GABAReceptor, GABA Receptor, GABA, Lotilaner, Ls-GABA1, Parasite, inhibit, Inhibitor

Compound Identifiers

PubChem CID

76959255