Lorediplon

SKU: orb1296263

Description

Lorediplon

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 917393-39-6
• MW: 394.42
• Purity: 99.19%
• Formula: C₂₀H₁₅FN₄O₂S
• SMILES: CN(C(C)=O)c1cc(ccc1F)-c1ccnc2c(cnn12)C(=O)c1cccs1
• Target: GABA Receptor
• Solubility: DMSO:100 mg/mL (253.54 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.14 mM)

Bioactivity

• In Vivo:
  in vivo Lorediplon inhibits spontaneous motor activity and increase the duration of sleep in mice (ED50s = 0.13 and 1.2 mg/kg, respectively. It selectively inhibits spontaneous motor activity, which is driven by α1 subunit-containing GABAA receptors, over modification of muscular tone in mice, an α2 subunit-containing GABAA receptor-stimulated activity. Lorediplon (0.13 and 1.2 mg/kg) also decreases latency to slow-wave sleep (SWS) and paradoxical sleep (PS) in mice.

Storage & Handling

• Storage: keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

γ-Aminobutyric acid Receptor, Inhibitor, GABAA, GABA Receptor, GABAReceptor, Gamma-aminobutyric acid Receptor, Lorediplon, inhibit

Compound Identifiers

PubChem CID

12004146