Longdaysin

SKU: orb1221024

Description

Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).

Key Properties

• CAS Number: 1353867-91-0
• MW: 335.33
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₆F₃N₅
• SMILES: CC(C)n1cnc2c(NCc3cccc(c3)C(F)(F)F)ncnc12
• Target: Casein Kinase
• Solubility: DMSO: 100 mg/mL (298.21 mM);Water: Insoluble

Bioactivity

• In Vivo:
  Animal model: MDA-MB-231 xenografts. Dosage: 5 mg/kg. Administration: i.p. , every 3 days for 3 weeks. Result: Decreased tumor cell density and proliferation (indicated by Ki-67). Reduced the expression of active and total β-catenin, and decreased the expression of phosphorylated and total LRP6, phosphorylated DVL2, and active and total β-catenin. Reduced mRNA expression of the Wnt target genes including Axin2, DKK1, LEF1, and Survivin.
• In Vitro:
  Western blot analysis. Cell line: HEK293T cells. Concentration: 0-50 μM. Incubation time: 24 h. Result: Reduced the levels of phosphorylated LRP6, total LRP6, phosphorylated DVL2, activated β-catenin, and total β-catenin.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Casein Kinase