Lobetyolinin

SKU: orb1684451

Description

Lobetyolinin, a bioactive compound isolated from Codonopsis pilosula, exhibits acetylcholinesterase (AChE) inhibitory and antiarrhythmic properties. This small molecule is utilized in neurological and cardiovascular research, with studies demonstrating its activity in both in vitro enzyme assays and in vivo models of arrhythmia.

Research Area

Neuroscience

Key Properties

• CAS Number: 142451-48-7
• MW: 558.57
• Purity: 99.72%
• Formula: C₂₆H₃₈O₁₃
• SMILES: O([C@@H]([C@@H](C#CC#C/C=C/C)O)/C=C/CCCO)[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O
• Target: Cholinesterase (ChE)
• Solubility: Ethanol:80 mg/mL (143.22 mM)

Bioactivity

• In Vivo:
  METHODS: Lobetyolinin (50 μM, 24 hours) was used to treat zebrafish larvae with 15 μM terfenadine for 2 hours, and the heartbeat was recorded under fluorescence. RESULTS:As a result, the heart rate of zebrafish larvae recovered to varying degrees, and Lobetyolinin showed better activity. METHODS: After 1 hour of treatment with 25 μM terfenadine, the heart rate decreased and irregular rhythm appeared. After 6 hours of pretreatment with Lobetyolinin, the electrocardiogram of adult zebrafish treated with it was measured. RESULTS:Lobetyolinin restored the heart rate of adult zebrafish, indicating that it has anti-arrhythmic effects.

Storage & Handling

• Storage: store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AChE, Lobetyolinin

Compound Identifiers

PubChem CID

145865807