LMP744 hydrochloride

SKU: orb1309471

Description

LMP744 hydrochloride

Research Area

Molecular Biology

Key Properties

• CAS Number: 308246-57-3
• MW: 488.92
• Purity: 98.44% (May vary between batches)
• Formula: C₂₄H₂₅ClN₂O₇
• SMILES: Cl.COc1cc2c3C(=O)c4cc5OCOc5cc4-c3n(CCCNCCO)c(=O)c2cc1OC
• Target: Topoisomerase
• Solubility: DMSO:5.56 mg/mL (11.37 mM)

Bioactivity

• In Vivo:
  LMP744 (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity.
  Read more...
• In Vitro:
  LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle.The GI50 value of LMP744 for NCI60 cells is 0.1 μM.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, LMP744, LMP-744, LMP744 hydrochloride, LMP744 Hydrochloride, LMP-744 hydrochloride, LMP-744 Hydrochloride, LMP 744, LMP 744 Hydrochloride, NSC706744, NSC-706744, NSC706744 hydrochloride, NSC706744 Hydrochloride, NSC-706744 Hydrochloride, MJ-III65, MJ-III65 Hydrochloride, MJ-III65 hydrochloride, NSC 706744, NSC 706744 Hydrochloride, Top1, Topoisomerase, Topo I

Compound Identifiers

PubChem CID

397887