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Linifanib
Catalog Number: orb1305372
| Catalog Number | orb1305372 |
|---|---|
| Category | Small Molecules |
| Description | Linifanib |
| Purity | 98.24% |
| MW | 375.4 |
| Biological Activity | Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and PDGFRβ (IC50: 66 nM). Linifanib may exhibit potent antiproliferative and apoptotic effects on tumor cells whose proliferation is dependent on mutant kinases, such as FMS-related tyrosine kinase receptor-3 (FLT3). |
| CAS Number | [796967-16-3] |
| Formula | C21H18FN5O |
| SMILES | Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 |
| Storage | -20°C |
| Note | For research use only |
Linifanib [orb1223985]
> 98% (HPLC)
796967-16-3
375.4
C21H18FN5O
1 g, 500 mg, 25 mg, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg
