Limonin

SKU: orb1305103

Description

Limonin (Citrolimonin) is a citrus-derived triterpenoid studied for its antiviral and antitumor properties. Research applications include investigating its mechanisms in vitro and its bioactivity in animal models, supporting its role in oncology and virology research.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 1180-71-8
• MW: 470.51
• Purity: 99.65%
• Formula: C₂₆H₃₀O₈
• SMILES: C[C@]12[C@]34[C@](O3)(C(=O)O[C@H]([C@]4(C)CC[C@@]1([C@]56[C@@](CC2=O)(C(C)(C)O[C@]5(CC(=O)OC6)[H])[H])[H])C=7C=COC7)[H]
• Target: Cytochromes P450,P-gp,HIV Protease,Apoptosis,Endogenous Metabolite
• Solubility: DMSO:50 mg/mL (106.27 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  Limonin is an effective antiproliferative agent that inhibits the proliferation of human hepatocellular carcinoma HepG2 cells by regulating cell apoptosis and the Wnt signaling pathway. Additionally, Limonin suppresses the replication of Human Immunodeficiency Virus-1 (HIV-1) in cultured human peripheral blood mononuclear cells (PBMC) with an EC50 of 60 μM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Citrolimonin, Dictamnolactone, EndogenousMetabolite, Endogenous Metabolite, Apoptosis, Obaculactone, Limonin, Limonoic acid 3,19:16,17 dilactone, HIV, HIV Protease, HIVProtease

Compound Identifiers

PubChem CID

179651