Limaprost

SKU: orb1707065

Description

Limaprost

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 74397-12-9
• MW: 380.52
• Purity: 99.89% (May vary between batches)
• Formula: C₂₂H₃₆O₅
• SMILES: CCCC[C@H](C)C[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCC\C=C\C(O)=O
• Target: PGE Synthase
• Solubility: DMSO:40 mg/mL (105.12 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.26 mM)

Bioactivity

• In Vivo:
  PGE1 and limaprost exhibited a novel pharmacological action that suppresses NGF expression in human IVD cells, and other prostanoids differentially regulated NGF expression. Limaprost has been used to treat patients with lumbar spinal stenosis in Japan and was proved to be effective in relieving symptoms.Platelet aggregation, adhesiveness, bleeding time, and thrombocytopenia induced by ADP and collagen infusion in guinea-pigs are inhibited by oral administration of Limaprost at the same doses or doses less than those relieving vasopressin-induced ST depression of ECG. Intra-coronary injection of Limaprost (1-100 ng/kg) in dogs causes a remarkable increase in coronary blood flow without any influence on heart rate, blood pressure, myocardial oxygen consumption, and redox potential. Limaprost given orally at more than 100 mg/kg relieves vasopressin-induced ST depression of rat electrocardiogram. Resistance in both large and small vessels of the dog coronary artery is decreased by intravenous injection of Limaprost (1-3 mg/kg) .
• In Vitro:
  By a concentration-dependent manner, Limaprost inhibits the IL-1-mediated induction of nerve growth factor (IC50: 70.9 nM human IVD cells) .

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

alprostadil, Antianginal, atherosclerotic, 17alpha,20-dimethyl-delta2-PGE1, 17a,20-dimethyl-δ2-PGE1, 17α,20-dimethyl-δ2-PGE1, adhesion, ADP, aggregation, ischaemic, inhibit, Limaprost, OP 1206, OP1206, OP-1206, ONO1206, ONO-1206, ONO 1206, Inhibitor, IL-1, platelet, Prostaglandin E synthase, PGE synthase, PGE1, PGE Synthase, PGESynthase, vasodilator

Compound Identifiers

PubChem CID

6438378