Levomepromazine

SKU: orb1707078

Description

Levomepromazine is an aliphatic phenothiazine with antipsychotic properties, functioning as a multi-receptor antagonist and a calcium release inducer. It is utilized in research models for neurodegenerative diseases, inflammation, and pain, based on its documented neuroprotective and antiviral activities in experimental studies.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 60-99-1
• MW: 328.47
• Purity: 99.15% (May vary between batches)
• Formula: C₁₉H₂₄N₂OS
• SMILES: C([C@@H](CN(C)C)C)N1C=2C(SC=3C1=CC=CC3)=CC=C(OC)C2
• Target: Virus Protease,Antifungal,Histamine Receptor,5-HT Receptor,Calcium Channel,Dopamine Receptor,Autophagy
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.04 mM);DMSO:30 mg/mL (91.33 mM)

Bioactivity

• In Vivo:
  Levomepromazine (5-20 mg/kg; Intraperitoneal injection) has analgesic, sedative and anti-injurious effects in mice .
• In Vitro:
  Levomepromazine(0.01-200 μM,72h) increased the CYP3A4 activity of HU1832 to 152% at 2.5 μM. Levomepromazine (10 μM, 24 h) reduced Japanese encephalitis virus (JEV) -induced Neuro2a cell death, decreased JEV RNA levels and viral titers, and significantly inhibited JEV protein translation/replication complex formation and ROS production. Levomepromazine (10 μM, 24 h) reduces inflammation in microglia by inducing autophagy.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Methotrimeprazine, Levomepromazine

Compound Identifiers

PubChem CID

72287