LAS101057

SKU: orb1707095

Description

LAS101057 is a potent, selective, and orally bioavailable A2B adenosine receptor antagonist. It is a valuable research tool for investigating asthma pathophysiology, enabling both in vitro binding studies and in vivo models of airway inflammation and hyperresponsiveness.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 925676-48-8
• MW: 335.34
• Purity: 99.03%
• Formula: C₁₈H₁₄FN₅O
• SMILES: Fc1cnccc1-c1ncc(NC(=O)C2CC2)nc1-c1cccnc1
• Target: Adenosine Receptor
• Solubility: H2O:< 0.1 mg/mL (insoluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.93 mM);DMSO:100 mg/mL (298.2 mM)

Bioactivity

• In Vivo:
  At 3 mg/kg, LAS101057 effectively prevents Acetyl-β-methylcholine-induced airway hyperresponsiveness (AHR), and at 10 mg/kg, it inhibits AHR to levels similar to those achieved by 1 mg/kg of Hexadecadrol.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

A2B, AdenosineReceptor, Adenosine Receptor, LAS 101057, LAS101057, LAS-101057

Compound Identifiers

PubChem CID

16071896