Larixol

SKU: orb1944102

Description

Larixol is a multi-target small molecule that inhibits fMLP-induced neutrophil activation by blocking key signaling pathways (Src, ERK, p38, AKT) and disrupting Gi protein βγ subunit interactions. It suppresses superoxide generation, cathepsin G release, and chemotaxis (IC50 ~2-3 μM), and its derivatives also inhibit FSGS-linked TRPC6 mutants, supporting research into inflammation and kidney disease.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1438-66-0
• MW: 306.48
• Formula: C₂₀H₃₄O₂
• SMILES: C[C@]12[C@@]([C@@H](O)CC(=C)[C@@H]1CC[C@](C=C)(C)O)(C(C)(C)CCC2)[H]
• Target: Akt

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

11335788