Lariciresinol

SKU: orb1297307

Description

Lariciresinol is a dietary enterolignan precursor with demonstrated antifungal activity via plasma membrane disruption. Research indicates it also exhibits anti-tumor properties, reducing mammary tumor growth and angiogenesis in both xenograft and carcinogen-induced rat models.

Research Area

Cardiovascular Research, Cell Biology, Infectious Disease & Virology, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 27003-73-2
• MW: 360.4
• Purity: 99.46% (May vary between batches)
• Formula: C₂₀H₂₄O₆
• SMILES: C(O)[C@@H]1[C@H](OC[C@@H]1CC2=CC(OC)=C(O)C=C2)C3=CC(OC)=C(O)C=C3
• Target: Apoptosis,Antifection,Antifungal,VEGFR,TGF-beta/Smad,glycosidase,Bcl-2 Family,NF-κB
• Solubility: DMSO:55 mg/mL (152.61 mM)

Bioactivity

• In Vitro:
  In this study, the antifungal properties and mode of action of Lariciresinol were investigated. Lariciresinol displays potent antifungal properties against several human pathogenic fungal strains without hemolytic effects on human erythrocytes. To understand the antifungal mechanism of action of Lariciresinol, the membrane interactions of Lariciresinol were examined. Fluorescence analysis using the membrane probe 3,3'-diethylthio-dicarbocyanine iodide (DiSC(3)-5) and 1,6-diphenyl-1,3,5-hexatriene (DPH), as well as a flow cytometric analysis with propidium iodide (PI), a membrane-impermeable dye, indicated that Lariciresinol was associated with lipid bilayers and induced membrane permeabilization.
  Read more...

Storage & Handling

• Storage: keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Lariciresinol, inhibit, Antifection, VEGFR

Compound Identifiers

PubChem CID

332427