L-Homocystine

SKU: orb1221374

Description

Homocystine is the double-bonded form of homocysteine but it occurs only transiently before being converted to the harmless cystathionine via a vitamin B6-dependent enzyme. Increasing evidence supports a role for an elevation of homocysteine in schizophrenia. It has been demonstrated that neural tube defects are related to a genetic defect in homocysteine metabolism. Sufficient intake of folic acid is believed to reduce this risk by enhancing methylation of homocysteine and its conversion to methionine thereby compensating for this genetic defect (homocystinuria). Plasma homocysteine levels are elevated when folate levels are in the lower half of the normal range.

Key Properties

• CAS Number: 626-72-2
• MW: 268.35
• Purity: >98% (HPLC)
• Formula: C₈H₁₆N₂O₄S₂
• SMILES: N[C@@H](CCSSCC[C@H](N)C(O)=O)C(O)=O
• Target: Endogenous Metabolite
• Solubility: DMSO: 1 mg/mL (3.73 mM; ultrasonic and adjust pH to 5 with HCl); H2O: 1 mg/mL (3.73 mM; ultrasonic and adjust pH to 2 with HCl)

Bioactivity

• In Vivo:
  A single or multiple doses of L-Homocystine administered to mice during organogenesis can aggravate the developmental disturbances caused by a single dose of VPA administered on GD 8. Whereas, VPA lowers significantly plasma FA and vitamin B12 concentrations, it has no direct impact on the homocysteine concentrations. Therefore, it is proposed that high levels of homocysteine disturb the FA, vitamin B12, and possibly methionine metabolism thus providing a favorable situation for VPA to interfere with the development of susceptible embryos.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Endogenous Metabolite