L-Dihydroorotic acid

SKU: orb1221440

Description

L-Dihydroorotic acid also known as (S)-45-dihydroorotate or dihydro-L-orotate belongs to the class of organic compounds known as alpha amino acids and derivatives. Within the cell L-dihydroorotic acid is primarily located in the cytoplasm and mitochondria. L-Dihydroorotic acid exists in all eukaryotes ranging from yeast to humans. L-Dihydroorotic acid participates in a number of enzymatic reactions. In particular L-Dihydroorotic acid can be biosynthesized from ureidosuccinic acid; which is catalyzed by the enzyme cad protein. In addition L-Dihydroorotic acid and quinone can be converted into orotic acid; which is mediated by the enzyme dihydroorotate dehydrogenase (quinone) mitochondrial. In humans L-dihydroorotic acid is involved in the pyrimidine metabolism pathway. L-Dihydroorotic acid is also involved in several metabolic disorders some of which include UMP synthase deficiency (orotic aciduria) the mngie (mitochondrial neurogastrointestinal encephalopathy) pathway Beta ureidopropionase deficiency and dihydropyrimidinase deficiency.

Key Properties

• CAS Number: 5988-19-2
• MW: 158.11
• Purity: >98% (HPLC)
• Formula: C₅H₆N₂O₄
• SMILES: OC(=O)[C@@H]1CC(=O)NC(=O)N1
• Target: Others
• Solubility: DMSO:196.1 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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