L 756423

SKU: orb1703180

Description

L 756423 is a potent, selective, and competitive HIV-1 protease inhibitor with a Ki of 0.049 nM. It effectively inhibits viral spread in HIV(IIIb)-infected MT-2 cell cultures at sub-nanomolar concentrations, making it a valuable research tool for in vitro antiviral studies relevant to AIDS.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 216863-66-0
• MW: 652.82
• Purity: 99.34% (May vary between batches)
• Formula: C₃₉H₄₈N₄O₅
• SMILES: N(C([C@H](CC1=CC=CC=C1)C[C@@H](CN2[C@H](C(NC(C)(C)C)=O)CN(CC3=CC=4C(O3)=CC=CC4)CC2)O)=O)[C@H]5C=6C(C[C@H]5O)=CC=CC6
• Target: HIV Protease
• Solubility: DMSO:50 mg/mL (76.59 mM)

Bioactivity

• In Vitro:
  MK-944a (L-756,423) is selective and competitively inhibits HIV-1 PR with a K(i) value of 0.049 nM. It stops the spread of the HIV(IIIb)-infected MT4 lymphoid cells at 25.0-50.0 nM, even in the presence of alpha(1) acid glycoprotein, human serum albumin, normal human serum, or fetal bovine serum.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

L 756423, MK 944a, MK944a, MK-944a, L-756,423, L756423, L-756423, HIV Protease, HIVProtease

Compound Identifiers

PubChem CID

5481481