L-006235

SKU: orb1306274

Description

L-006235 is a highly potent and reversible cathepsin K inhibitor, exhibiting an IC50 of 0.25 nM. This small molecule is a valuable research tool for investigating osteoclast function and bone resorption processes in both in vitro cellular assays and in vivo models of bone-related diseases.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 294623-49-7
• MW: 466.6
• Purity: 99.37%
• Formula: C₂₄H₃₀N₆O₂S
• SMILES: CN1CCN(CC1)c1nc(cs1)-c1ccc(cc1)C(=O)NC1(CCCCC1)C(=O)NCC#N
• Target: Cysteine Protease
• Solubility: DMSO:50 mg/mL (107.16 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.29 mM)

Bioactivity

• Target IC50:
  Cathepsin K:5 nM (IC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

resorption, L235, L-235, Inhibitor, inhibit, loss, L 006235, L 235, L006235, L-006235, collagen, degradation, Cysteine Protease, CysteineProtease, bone, Cathepsin, cathepsin K

Compound Identifiers

PubChem CID

9912381