Kuwanon A

SKU: orb1296067

Description

Kuwanon A is a flavone compound derived from Morus alba L. that potently inhibits nitric oxide production with an IC50 of 10.5 µM. This activity supports its research use in studying inflammatory pathways and oxidative stress in both cellular and animal models of disease.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 62949-77-3
• MW: 420.45
• Purity: 99.96% (May vary between batches)
• Formula: C₂₅H₂₄O₆
• SMILES: CC(C)=CCc1c(oc2cc(O)cc(O)c2c1=O)-c1ccc(O)c2C=CC(C)(C)Oc12
• Target: NO Synthase
• Solubility: DMSO:Soluble

Bioactivity

• Target IC50:
  Nitric oxide (NO):10.5 μM
• In Vitro:
  Kuwanon A exhibits significant inhibitory activity on the differentiation of 3T3-L1 adipocytes, with triglyceride (TG) inhibition values of 47.1% .
• Cell Research:
  RAW264.7 cells are treated with Kuwanon A (3, 10, 20, 30, 100 μM). Cell viability is measured using the MTT assay.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, NOS, Kuwanon A, NOSynthase, Nitric oxide synthases, nitric oxide, NO Synthase

Compound Identifiers

PubChem CID

44258296