KT-333 ammonium

SKU: orb2565896

Description

KT-333 ammonium is a molecular glue degrader that selectively targets STAT3 for ubiquitin-proteasome degradation by recruiting the VHL E3 ligase. It demonstrates potent antitumor activity in research models of hematologic malignancies such as T-cell lymphomas and leukemias, supporting its use in both in vitro and in vivo oncology studies.

Research Area

Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2839758-34-6
• MW: 1274.81
• Formula: C₆₀H₇₇ClN₁₁O₁₄PS
• SMILES: ClC(C(CCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)=O)=O)=CC=C4)=C4OC[C@H](CCC(N)=O)NC([C@H]5N6[C@](CCN(C[C@@H](C6=O)NC(C7=CC8=CC(C(P(O)([O-])=O)=O)=CC=C8N7)=O)C(C)=O)([H])CC5)=O.[NH4+]
• Target: Molecular Glues,STAT

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172395678