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KRIBB11

SKU: orb1225248

Description

KRIBB11 is a small molecule heat shock factor 1 (HSF1) inhibitor with IC50 of 1.2 uM; inhibits HSF1 downstream target proteins HSP70 and HSP72 synthesis, induces growth arrest and apoptosis in HCT-116 cells, inhibits HSF1-dependent recruitment of p-TEFb to the hsp70 promoter; inhibits tumor growth without body weight loss in mice model.

Images & Validation

Key Properties

CAS Number342639-96-7
MW284.27338
Purity>98% (HPLC)
FormulaC13H12N6O2
SMILESO=[N+](C1=CC=C(NC)N=C1NC2=CC3=C(NN=C3)C=C2)[O-]
TargetHSP
SolubilityDMSO: ≥ 27 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

KRIBB-11 | KRIBB 11

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KRIBB11 (orb1225248)

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Available Sizes

Select a size below

5 mg
$ 90.00
10 mg
$ 130.00
25 mg
$ 270.00
50 mg
$ 440.00
100 mg
$ 840.00
200 mg
$ 1,170.00
500 mg
$ 1,770.00