KH7

SKU: orb1308155

Description

KH7 is a cell-permeable, selective inhibitor of soluble adenylyl cyclase (sAC) with an IC₅₀ of 3-10 µM. It is widely used in research to probe sAC-mediated cAMP signaling in cellular models and has been applied in studies of sperm motility, mitochondrial function, and neuronal signaling pathways.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 330676-02-3
• MW: 419.3
• Purity: 98.43% (May vary between batches)
• Formula: C₁₇H₁₅BrN₄O₂S
• SMILES: CC(Sc1nc2ccccc2[nH]1)C(=O)N\N=C\c1cc(Br)ccc1O
• Target: cAMP,Adenylate cyclase
• Solubility: H2O:< 0.1 mg/mL (insoluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.54 mM);DMSO:100 mg/mL (238.49 mM)

Bioactivity

• Target IC50:
  sAC:3-10 μM
• In Vitro:
  KH7 prevents the generation of CaSF. KH7 (10 μM) blocks this capacitation-induced cAMP increase. At higher concentrations (50 μM), 5- to 10-fold above its IC50 but still selective for sAC relative to tmACs, KH7 resulted in a significant decrease in the basal cAMP accumulation in sperm regardless of the incubation medium. The myocytes exert a negative inotropic effect (NIE) of approximately 20%, in the presence of KH7. This suggesting that sAC is involved in the normal generation of basal cardiac contractility [1,2].
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Adenylate Cyclase, Adenylyl cyclase, inhibit, KH 7, KH7, KH-7, Inhibitor, recombinant sACt, sAC

Compound Identifiers

PubChem CID

135496218