KDU691

SKU: orb1301803

Description

KDU691

Research Area

Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 1513879-19-0
• MW: 419.86
• Purity: 98.87%
• Formula: C₂₂H₁₈ClN₅O₂
• SMILES: CNC(=O)c1ccc(cc1)-c1cnc2cnc(cn12)C(=O)N(C)c1ccc(Cl)cc1
• Target: PI4K,Parasite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.53 mM);DMSO:150 mg/mL (357.26 mM)

Bioactivity

• In Vivo:
  KDU691 was evaluated for in vivo activity in rhesus macaques infected with P. cynomolgi sporozoites. The prophylactically treated monkeys failed to become blood smear positive, while untreated control animals showed normal parasitemia development (primary parasitemia at day 8.9 p.i., with the first relapse within a month). Thus, 5-day oral treatment with 20 mg/kg of KDU691 shortly after infection eradicated all liver-stage parasites, including hypnozoites.
• Animal Research:
  Sporozoites were harvested from P. cynomolgi-infected mosquitoes, washed with phosphate-buffered saline (PBS), and diluted to 100,000 sporozoites (spz)/ml in PBS. One-milliliter aliquots of sporozoites were prepared and injected into monkeys via intravenous injection. During treatment, monkeys were weighed daily and received the compound via gavage, followed by gastric feeding. Monkeys in the prophylaxis groups were treated 20 min after the i.v. sporozoite injection. The other monkeys were treated when all the monkeys in the experiment (except those in the prophylaxis group) were blood-stage patent (at day 11 p.i.). To kill the blood-stage parasites, all monkeys received a 5-day treatment of 7.5 mg/kg of body weight of chloroquine (CQ), during compound dosing. KDU691 was formulated in 0.5% methylcellulose and 0.5% Tween 80 in water. LMV599 was formulated as a solid dispersion in a solution containing 5.6% (wt/wt) Tween 80 44.4% hydroxypropyl methylcellulose (HPMC) E3 38.9% Soluplus 11.1% vitamin E d-alphatocopheryl polyethylene glycol 1000 succinate.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, KDU 691, KDU691, KDU-691, liver, Parasite, falciparum, gametocytes, blood, plasmodium, ring-stage, stage, schizonts, PI4 kinases, PI4K, Phosphatidylinositol 4 kinases

Compound Identifiers

PubChem CID

90157166