K-604 dihydrochloride

SKU: orb1309518

Description

K-604 dihydrochloride is a potent and selective ACAT-1 inhibitor, demonstrating an IC50 of 0.45±0.06 µM. This small molecule is a valuable research tool for investigating cholesterol metabolism and atherosclerosis in both cellular and animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 217094-32-1
• MW: 575.64
• Purity: 99.10%
• Formula: C₂₃H₃₂Cl₂N₆OS₃
• SMILES: Cl.Cl.CSc1cc(C)nc(SC)c1NC(=O)CN1CCN(CCSc2nc3ccccc3[nH]2)CC1
• Target: Acyltransferase
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (4.34 mM);DMSO:62.5 mg/mL (108.57 mM)

Bioactivity

• Target IC50:
  ACAT2:102.85 μM|ACAT1:0.45 μM
• In Vitro:
  a novel ACAT inhibitor, K-604. The IC(50) values of K-604 for human ACAT-1 and ACAT-2 were 0.45 and 102.85 micromol/L, respectively, indicating that K-604 is 229-fold more selective for ACAT-1. Kinetic analysis indicated that the inhibition was competitive with respect to oleoyl-coenzyme A with a K(i) value of 0.378 micromol/L. Exposure of human monocyte-derived macrophages to K-604 inhibited cholesterol esterification with IC(50) of 68.0 nmol/L. Furthermore, cholesterol efflux from THP-1 macrophages to HDL(3) or apolipoprotein A-I was enhanced by K-604.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

K604, K-604, K604 dihydrochloride, K604 Dihydrochloride, K-604 Dihydrochloride, K 604 dihydrochloride, K 604, K 604 Dihydrochloride, inhibit, Inhibitor, mono- acylglycerol acyltransferase, Diglyceride acyltransferase, Diacylglycerol acyltransferase, ACAT-2, ACAT-1, Acyltransferase, acyl-CoA:cholesterol acyltransferase

Compound Identifiers

PubChem CID

22272715