K-14585

SKU: orb1700257

Description

K-14585 is a selective PAR2 antagonist that inhibits PAR2-mediated NF-κB activation and IL-8 production induced by agonists like SLIGKV. Interestingly, it can elevate IL-8 levels when administered alone. This compound is a valuable research tool for studying PAR2 signaling in inflammation, cancer, and pain models, applicable in both cellular and animal studies.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 880546-17-8
• MW: 915.95
• Formula: C₅₁H₅₆Cl₂N₈O₄
• SMILES: C(C=1C=2C(N(CC3=C(Cl)C=CC=C3Cl)C1)=CC=C(NC(NCC(N[C@H](C(N[C@H](C(NC(C4=CC=CC=C4)C5=CC=CC=C5)=O)CC6=CC=CC=C6)=O)CCCCN)=O)=O)C2)N7CCCC7
• Target: Others,Protease-activated Receptor,p38 MAPK,NF-κB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

11557006