JTE-952

SKU: orb1709360

Description

JTE-952 is a potent, orally bioavailable, and selective Type II CSF-1R inhibitor (IC50=13 nM) with demonstrated efficacy in a mouse collagen-induced arthritis model. This small molecule is a valuable research tool for studying macrophage biology, inflammation, and autoimmune disease mechanisms in both in vitro and in vivo settings.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 1255303-54-8
• MW: 518.6
• Formula: C₃₀H₃₄N₂O₆
• SMILES: C(=O)(N1CC(C1)C2=CC(OC)=C(OCC3=CC=C(C=C3)C4CC4)C=C2)C5=CC(COC[C@H](CO)O)=CC=N5
• Target: c-Fms,Histamine Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

49806372