JQAD1

SKU: orb1690076

Description

JQAD1

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 2417097-18-6
• MW: 932.95
• Purity: 98.87% (May vary between batches)
• Formula: C₄₈H₅₂F₄N₆O₉
• SMILES: O=C1[C@@]2(C=3C(CC2)=CC(NC(CCCCCCCCCCCNC=4C=C5C(=CC4)C(=O)N(C5=O)C6C(=O)NC(=O)CC6)=O)=CC3)OC(=O)N1CC(N(CC7=CC=C(F)C=C7)[C@H](C(F)(F)F)C)=O
• Target: Histone Acetyltransferase,PARP,PROTACs,Apoptosis,Epigenetic Reader Domain,Caspase
• Solubility: DMSO:90 mg/mL (96.47 mM)

Bioactivity

• In Vivo:
  JQAD1 (40 mg/kg; i.p.; once daily for 21 days) inhibits tumor growth in NSG mice transplanted with Kelly NB cells .
• In Vitro:
  JQAD1 (0.5 or 1 μ M; 6-96 h) treatment led to early time-dependent induction of sub-G1 peak, indicating that apoptosis of Kelly and NGP cells. JQAD1 (1 μ M; 12-36 h) induced apoptosis of Kelly NB cell. JQAD1 (0.5 μ M; 24 h) treated cells showed up-regulation of BH3 effectors BIM, BID and PUMA, pro-apoptotic mediator BAX and its inhibitors BCL2 and MCL1. JQAD1 (0.5 and 1 μ M; 24 h) destroy expression of MYCN. JQAD1 (0.5 μ M; 24 h) lead to H3K27ac deletion on chromatin. JQAD1 (1.2 nM-20 μ M; 5 days) has extensive CRBN-dependent anti-tumor activity across cancer cell lines. JQAD1 induced degradation of EP300 in a time-dependent manner, at the earliest 16 hours .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

JQAD 1, JQAD1, JQAD-1, EpigeneticReaderDomain, Epigenetic Reader Domain, EP300

Compound Identifiers

PubChem CID

162615894