JNJ-61432059

SKU: orb1308172

Description

JNJ-61432059 is a potent, orally bioavailable, and selective negative allosteric modulator of TARP γ‑8-associated AMPA receptors (pIC50 = 9.7). This compound is a valuable research tool for investigating AMPA receptor function in neurological disorders and has demonstrated utility in both in vitro assays and in vivo preclinical models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2035814-50-5
• MW: 443.47
• Purity: 98.13%
• Formula: C₂₅H₂₂FN₅O₂
• SMILES: OC1CCN(CC1)c1nccc2c(c(nn12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1
• Target: iGluR
• Solubility: DMSO:65 mg/mL (146.57 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.51 mM)

Bioactivity

• Target IC50:
  AMPAR:(pic50)9.7
• In Vivo:
  In mouse hippocampus, Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMPAR, inhibit, Ionotropic glutamate receptors, JNJ 61432059, JNJ61432059, JNJ-61432059, iGluR, Inhibitor

Compound Identifiers

PubChem CID

122656119