JNJ-40411813

SKU: orb1296209

Description

JNJ-40411813 (ADX-71149) is a positive allosteric modulator of the metabotropic glutamate 2 receptor (mGlu2R) with an EC50 of 147 nM. This compound is a valuable research tool for investigating mGlu2R function in neuropsychiatric disorders, facilitating both in vitro binding studies and in vivo behavioral experiments.

Research Area

Neuroscience

Key Properties

• CAS Number: 1127498-03-6
• MW: 344.88
• Purity: 99.74% (May vary between batches)
• Formula: C₂₀H₂₅ClN₂O
• SMILES: CCCCn1ccc(N2CCC(CC2)c2ccccc2)c(Cl)c1=O
• Target: GluR
• Solubility: DMSO:24 mg/mL (69.59 mM)

Bioactivity

• Target IC50:
  mGluR2:147 nM (EC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, JNJ40411813, JNJ-40411813, JNJ 40411813, inhibit, mGluR2, mGluR, Metabotropic glutamate receptors, ADX71149, ADX-71149, ADX 71149

Compound Identifiers

PubChem CID

25195461