JNJ 303

SKU: orb1299623

Description

JNJ 303 is a selective small molecule inhibitor of the IKs potassium channel with an IC50 of 64 nM. It is a valuable research tool for studying cardiac electrophysiology and arrhythmia mechanisms in both cellular assays and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 878489-28-2
• MW: 440.98
• Purity: 99.28%
• Formula: C₂₁H₂₉ClN₂O₄S
• SMILES: CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1[C@H]2C[C@H]3C[C@@H]1C[C@](C3)(C2)NS(C)(=O)=O
• Target: Potassium Channel
• Solubility: DMSO:11 mg/mL (24.94 mM)

Bioactivity

• Target IC50:
  IKs:64 nM
• In Vitro:
  Optical mapping was used to measure action potential durations (APDs) in the presence of the IKs blocker JNJ-303 and the IKr blocker E-4031. JNJ-303 alone did not increase APD. However, under isoprenaline (ISO), both the application of JNJ-303 and additional E-4031 significantly increased APD. With JNJ-303, ISO decreased APD significantly more in the epicardium as compared to the endocardium, with subsequent application E-4031 increasing mid- and endocardial APD80 more significantly than in the epicardium. We found that β-AR stimulation significantly augmented the effect of IKs blocker JNJ-303, in contrast to the reduced effect of IKr blocker E-4031.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, KcsA, IKs, JNJ 303, inhibit, JNJ303, JNJ-303, Potassium Channel, PotassiumChannel

Compound Identifiers

PubChem CID

11575823