JHU37160

SKU: orb1298442

Description

JHU37160 is a potent and selective DREADD agonist, exhibiting high affinity and efficacy at both hM3Dq and hM4Di receptors. This tool compound is widely used in neuroscience research for the chemogenetic manipulation of specific neuronal circuits in both in vitro cellular assays and in vivo animal models to study behavior and neural function.

Research Area

Neuroscience

Key Properties

• CAS Number: 2369979-68-8
• MW: 358.84
• Purity: 99.87% (May vary between batches)
• Formula: C₁₉H₂₀ClFN₄
• SMILES: CCN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c(F)cccc12
• Target: AChR
• Solubility: DMSO:72 mg/mL (200.65 mM);Ethanol:72 mg/mL (200.65 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.57 mM)

Bioactivity

• Target IC50:
  M3Dq DREADD (human):18.5 nM (EC50)|M4Di DREADD (human):0.2 nM (EC50)
• In Vivo:
  JHU 37160 exhibits high in vivo DREADD potency. It exhibits selective [3H]clozapine displacement from DREADDs in brain tissue from WT and D1-DREADD mice
• In Vitro:
  JHU 37160 is a potent agonist of DREADD with high potency and efficacy in fluorescent and BRET-based assays in HEK-293 cells, whereas no responses are observed in untransfected HEK-293 cells

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Clozapine, DREADD, M3 mAChR, mAChR, Inhibitor, Muscarinic acetylcholine receptor, JHU37160, JHU-37160, JHU 37160, inhibit, hM3Dq, hM4Di

Compound Identifiers

PubChem CID

139033723