JHU-083

SKU: orb3054177

Description

JHU-083 is a selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b+ cells. JHU-083 also experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals.

Key Properties

• CAS Number: 1998725-11-3
• MW: 312.37
• Purity: >98% (HPLC)
• Formula: C₁₄H₂₄N₄O₄
• SMILES: [C@H](NC([C@H](CC(C)C)N)=O)(CCC(C=[N+]=[N-])=O)C(OCC)=O
• Solubility: Ethanol : 133.33 mg/mL (426.85 mM; ultraphonic) DMSO : 100 mg/mL (320.14 mM; ultraphonic; ) H2O : 50 mg/mL (160.07 mM; ultraphonic)

Bioactivity

• In Vivo:
  Animal model: Male 7-to 8-week-old C57BL/6J (C57) mice (25-30 g) with chronic social defeat stress (CSDS). Dosage: 1.82 mg/kg. Administration: PO; every other day for 12 days. Result: Ameliorated social avoidance behavior and anhedonia-like behavior induced by CSDS.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only