JBJ-07-149

SKU: orb2814460

Description

JBJ-07-149 is a potent, selective inhibitor of the EGFRL858R/T790M mutant (IC50 = 1.1 nM). It demonstrates anti-proliferative activity in Ba/F3 cells, with efficacy significantly enhanced in combination with Cetuximab. This compound is also a key chemical precursor for synthesizing the PROTAC molecule [DDC-01-163], supporting targeted protein degradation research.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 2140807-58-3
• MW: 510.61
• Formula: C₂₈H₂₆N₆O₂S
• SMILES: O=C1C2=CC(=CC=C2CN1C(C(=O)NC3=NC=CS3)C=4C=CC=CC4)C=5C=NC(=CC5)N6CCNCC6
• Target: EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

138534234