Itraconazole-d9

SKU: orb3138929

Description

Itraconazole-d9 is the deuterated form of Itraconazole. Itraconazole (R51211) is a triazole antifungal agent with potent oral activity as a Hedgehog signaling pathway antagonist, exhibiting an IC50 of approximately 800 nM. It effectively inhibits lanosterol 14α-demethylase (Cytochrome P450), thus preventing the conversion of lanosterol to ergosterol. Additionally, Itraconazole exhibits anti-cancer and anti-angiogenic properties and acts as an oxysterol-binding protein (OSBP) inhibitor.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1309272-50-1
• MW: 714.69
• Formula: C₃₅H₃₈Cl₂N₈O₄
• SMILES: C([C@]1(O[C@@H](COC2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)N5C(=O)N(C(C(C([2H])([2H])[2H])([2H])[2H])(C([2H])([2H])[2H])[2H])N=C5)CO1)C6=C(Cl)C=C(Cl)C=C6)N7C=NC=N7
• Target: Cytochromes P450,Autophagy,Antibiotic,Antifungal,Hedgehog/Smoothened,Antibacterial

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Cytochromes P450,Autophagy,Antibiotic,Antifungal,Hedgehog/Smoothened,Antibacterial