ISX-1

SKU: orb1703346

Description

ISX-1 is a small molecule that suppresses adipocyte differentiation while enhancing osteoblast formation. This dual activity makes it a valuable research tool for investigating bone-related disorders such as osteoporosis and osteopenia in both cellular and animal models.

Research Area

Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 909207-35-8
• MW: 302.35
• Purity: 98.73% (May vary between batches)
• Formula: C₁₄H₁₄N₄O₂S
• SMILES: C(NCCCN1C=CN=C1)(=O)C=2C=C(ON2)C3=CC=CS3
• Target: Others
• Solubility: DMSO:3.03 mg/mL (10.02 mM)

Bioactivity

• In Vitro:
  In human bone marrow mesenchymal stem cells, ISX-1 (0-33 μM) inhibits the mRNA induction of PPARγ and FABP4 genes under the adipogenic differentiation of hBMSCs and promotes TCF/LEF-mediated gene transcription. ISX-1 inhibits the accumulation of intracellular lipid droplets(IC50 = 1.9 μM) and stimulated ALP activity(EC50 = 1.2 μM) in a dose-dependent manner.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ISX1, ISX-1, ISX 1

Compound Identifiers

PubChem CID

3235911