Isovaleramide

SKU: orb1310689

Description

Isovaleramide (3-Methylbutanamide) is a natural anticonvulsant agent isolated from Valeriana pavonii. It functions as an inhibitor of hepatic alcohol dehydrogenases, making it a useful research tool for neurological and enzymology studies in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 541-46-8
• MW: 101.15
• Purity: 99.47% (May vary between batches)
• Formula: C₅H₁₁NO
• SMILES: CC(C)CC(N)=O
• Target: GABA Receptor,Dehydrogenase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (19.77 mM);Ethanol:16 mg/mL (158.18 mM);DMSO:75 mg/mL (741.47 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  At a concentration of 0.15%, Isovaleramide induces the formation of nitrile hydratase in Rhodococcus sp. YH 3-3. In in vitro assays, 300 μM Isovaleramide inhibits 42% of 3H-FNZ binding to its target site. At concentrations up to 1000 μM, Isovaleramide does not affect the binding and uptake assays of various neurotransmitters in vitro, suggesting that its mechanism of action does not involve direct receptor-mediated effects.
• In Vitro:
  Research on the reproductive toxicity of Isovaleramide in mice, rats, and rabbits demonstrates its potential to be significantly lower than that of VPA. Oral administration of Isovaleramide at a dose of 100 mg/kg resulted in a 90% protection index against maximal electroshock seizures in mice.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Isovaleramide, inhibit, Inhibitor, Alcohol DHO, 3-Methylbutanamide

Compound Identifiers

PubChem CID

10930