Isosaponarin

SKU: orb1689989

Description

Isosaponarin

Research Area

Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 19416-87-6
• MW: 594.52
• Purity: 99.12% (May vary between batches)
• Formula: C₂₇H₃₀O₁₅
• SMILES: OC1=C2C(OC(=CC2=O)C3=CC=C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C=C3)=CC(O)=C1[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O
• Target: PKC,TGF-beta/Smad
• Solubility: DMSO:100 mg/mL (168.2 mM)

Bioactivity

• In Vivo:
  Methods: A single oral dose of 50 mg/kg Isosaponarin was administered to 6-week-old female ICR mice to investigate its intestinal metabolism as well as absorption and excretion in the body. Results: Isosaponarin was metabolized to Isovitexin in the intestine, and most of it was not absorbed but excreted via feces.
• In Vitro:
  Methods: Human fibroblasts were treated with Isosaponarin at concentrations of 0.001–0.1 μg/mL for 24 hours to evaluate its effects on collagen synthesis and the expression of related proteins. Results: Isosaponarin promoted collagen synthesis, which was closely associated with the upregulation of TβR-II and P4H production.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Isosaponarin, TGF-β/Smad

Compound Identifiers

PubChem CID

154105