ISOPIMPINELLIN

SKU: orb1222201

Description

Antiviral, anti HIV.

Key Properties

• CAS Number: 482-27-9
• MW: 246.22
• Purity: >98% (HPLC)
• Formula: C₁₃H₁₀O₅
• SMILES: COc1c2ccoc2c(OC)c2oc(=O)ccc12
• Target: CDK
• Solubility: In Vitro: DMSO : 50 mg/mL (203.07 mM)

Bioactivity

• In Vivo:
  Isopimpinellin (oral gavage, 35-150 mg/kg) inhibits B[a]P-DNA adduct formation and DMBA–DNA adduct formation in SENCAR mice with skin tumor. Animal model: Female SENCAR mice (7-9 weeks of age) were fed AIN-76A semi-purified diet (Dyets, Bethlehem, PA) for 2 weeks prior to and during the study. Dosage: 35–150 mg/kg. Administration: Oral gavage, suspended in 0.1 mL corn oil at 24 h and 2 h prior to topical treatment with [3H]B[a]P (200 nmol, 1 Ci/mmol) or [3H]DMBA (10 nmol, 10 Ci/mmol) (each in 0.2 mL acetone). Result: Significantly inhibited B[a]P-DNA adduct formation by 37 and 26%, respectively. Isopimpinellin (35, 70 and 150 mg/kg) blocked DMBA–DNA adduct formation by 23, 56 and 69%, respectively.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CDK