Isoborneol

SKU: orb1299326

Description

Isoborneol

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 124-76-5
• MW: 154.25
• Purity: ≥95%
• Formula: C₁₀H₁₈O
• SMILES: CC1(C)[C@@H]2CC[C@@]1(C)[C@H](O)C2
• Target: HSV
• Solubility: DMSO:9 mg/mL (58.35 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (6.48 mM)

Bioactivity

• In Vitro:
  Isoborneol, a monoterpene and a component of several plant essential oils, showed dual viricidal activity against herpes simplex virus 1 (HSV-1). First, it inactivated HSV-1 by almost 4 log10 values within 30 min of exposure, and second, isoborneol at a concentration of 0.06% completely inhibited viral replication, without affecting viral adsorption. Isoborneol did not exhibit significant cytotoxicity at concentrations ranging between 0.016% and 0.08% when tested against human and monkey cell lines. Isoborneol specifically inhibited glycosylation of viral polypeptides based on the following data: (1) the mature fully glycosylated forms of two viral glycoproteins gB and gD were not detected when the virus was replicated in the presence of isoborneol, (2) no major changes were observed in the glycosylation pattern of cellular polypeptides between untreated and isoborneol treated Vero cells, (3) isoborneol did not affect the glycosylation of gB produced from a copy of the gB gene resident in the cellular genome, and (4) other monoterpenes such as 1,8-cineole and borneol, a stereoisomer of isoborneol, did not inhibit HSV-1 glycosylation.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HSV-1, HSV, Isoborneol, nervous, DL-Isoborneol, (±)-Isoborneol, ROS, SH-SY5Y, plants

Compound Identifiers

PubChem CID

6321405