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iRucaparib-AP6

SKU: orb1707924

Description

iRucaparib-AP6 is a PROTAC-based, non-trapping PARP1 degrader that eliminates both the enzymatic and scaffolding functions of PARP1. This tool compound is useful for in vitro and in vivo studies investigating PARP1's roles in DNA repair and cancer biology.

Research Area

Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2410557-00-3
MW886.96
FormulaC46H55FN6O11
SMILESO=C1NCCC2=C(NC3=CC(F)=CC1=C32)C4=CC=C(C=C4)CN(C)CCOCCOCCOCCOCCOCCOCCNC5=CC=CC=6C(=O)N(C(=O)C56)C7C(=O)NC(=O)CC7
TargetPARP,PROTACs

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

iRucaparib-AP6 (orb1707924)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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