IRAK4 modulator-2

SKU: orb3027372

Description

IRAK4 modulator-2 (Compound 5) is a selective dual inhibitor of IRAK4 and IRAK1, with IC₅₀ values of 0.005 μM and 0.97 μM respectively. It may be employed in research concerning autoimmune and inflammatory diseases such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 1356013-27-8
• MW: 399.87
• Purity: 99.84%
• Formula: C₂₀H₂₂ClN₅O₂
• SMILES: O=C(NC1=CC(Cl)=CC=C1N2CCC(CC2)C(O)C)C=3C=NN4C=CC=NC34
• Target: IRAK

Bioactivity

• Target IC50:
  IRAK4:0.005 μM|IRAK1:0.97 μM

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

N-[5-Chloro-2-[4-(1-hydroxyethyl)-1-piperidinyl]phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[5-chloro-2-[4-(1-hydroxyethyl)-1-piperidinyl]phenyl]-

Quick Database Links

Gene Symbol

IRAK