IQB-782

SKU: orb1709402

Description

IQB-782 is a mucolytic research compound that acts as a thrombin-activatable fibrinolysis inhibitor (TAFI) inhibitor. It reduces mucin viscosity in vitro and has demonstrated protective effects against tobacco smoke-induced respiratory obstruction in rat models, supporting its utility in obstructive lung disease research.

Research Area

Metabolism Research

Key Properties

• CAS Number: 40454-21-5
• MW: 163.2
• Purity: >99.99% (May vary between batches)
• Formula: C₄H₉N₃O₂S
• SMILES: [C@@H](NC(=N)N)(C(O)=O)CS
• Target: Amino Acids and Derivatives,Others

Bioactivity

• Target IC50:
  Carboxypeptidase B:12 μM|Carboxypeptidase N:49 μM|TAFI:(Kiapp)0.14 μM |TAFI:0.14 μM
• In Vitro:
  IQB-782 exhibits inhibitory effects on TAFI-related carboxypeptidases, with IC50 values of 49 μM and 12 μM for CPN and CPB, respectively.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TAFI, IQB 782, IQB782, IQB-782

Compound Identifiers

PubChem CID

38477