Inz-1

SKU: orb1305056

Description

Inz-1

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 897776-15-7
• MW: 266.29
• Purity: 98.57% (May vary between batches)
• Formula: C₁₆H₁₄N₂O₂
• SMILES: C(C(OC)=O)N1N=C(C=2C1=CC=CC2)C3=CC=CC=C3
• Target: Cytochromes P450,Antifungal
• Solubility: DMSO:45 mg/mL (168.99 mM)

Bioactivity

• Target IC50:
  Cytochrome bc1 (mitochondrial):8.092 μM(yeast)|Cytochrome bc1 (mitochondrial):45.320 μM(human)
• In Vitro:
  Inz-1 against Candida and HepG2 respiring growth with IC50 values of 1.655 uM and >32 μM, respectively. Inz-1 (0-16 μM; 24 hours) inhibits the growth of the model yeast S. cerevisiae (strain BY4741) and C. albicans (SC5314) in media containing glucose or glycerol as the sole carbon source, while only mildly slowing growth in glucose. Inz-1 (0-100 μM; 24 hours) shows inhibition of yeast cytochrome B enzymatic activity in a concentration -dependent manner in both wild-type and F90Y mutant mitochondria. It exhibits inhibition of cytochrome bc1 from both S. cerevisiae and C. albicans with IC50 value of 2.5 μM and 8.0 μM, respectively. Inz-1 (0-100 μM; 24 hours) inhibits proliferation under forced respiration conditions only at 32 μM and only mildly at that concentration.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

drug-resistance, Cytochrome Bc 1, Cytochrome P450, CYPs, cell, Candida albicans, antifungal, inhibit, Inz 1, Inz1, Inz-1, mitochondrial cytochrome bc1, Fungal, Fluconazole, Inhibitor, yeast

Compound Identifiers

PubChem CID

3243873