Intepirdine

SKU: orb1307467

Description

Intepirdine (GSK-742457) is a potent and selective 5-HT6 receptor antagonist investigated for Alzheimer's Disease. It has been utilized in both in vitro binding assays and in vivo cognitive studies in animal models to explore its potential therapeutic effects.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 607742-69-8
• MW: 353.44
• Purity: 98.63%
• Formula: C₁₉H₁₉N₃O₂S
• SMILES: S(=O)(=O)(C1=CC2=C(C(=CC=C2)N3CCNCC3)N=C1)C4=CC=CC=C4
• Target: 5-HT Receptor
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.66 mM);Ethanol:2 mg/mL (5.66 mM);DMSO:70 mg/mL (198.05 mM)

Bioactivity

• Target IC50:
  5-HT6:9.63(pKi)
• In Vitro:
  SB-742457 is a selective 5-HT6 receptor antagonist with cognition, memory, and learning-enhancing effects. SB-742457 is a novel cognitive enhancing agent for Alzheimer's disease. SB-742457 is a potential agent added to stablize donepezil treatment in subjects with mild-to-moderate Alzheimer's disease.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5HTReceptor, 5HT Receptor, 5-hydroxytryptamine Receptor, 5-HT6, 5-HT Receptor, inhibit, Inhibitor, GSK742457, GSK-742457, GSK 742457, Intepirdine, SB 742457, SB742457, SB-742457, RVT 101, RVT101, RVT-101, Serotonin Receptor

Compound Identifiers

PubChem CID

11256720