Indotecan

SKU: orb1217476

Description

Indotecan is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).

Key Properties

• CAS Number: 915303-09-2
• MW: 478.49
• Purity: >98% (HPLC)
• Formula: C₂₆H₂₆N₂O₇
• SMILES: O=C1N(CCCN2CCOCC2)C3=C(C(C4=C3C=C(OCO5)C5=C4)=O)C6=C1C=C(OC)C(OC)=C6
• Target: Topoisomerase
• Solubility: In Vitro: DMSO : < 1 mg/mL (insoluble o)

Bioactivity

• In Vivo:
  Animal model: Female BALB/c mice (4-6 weeks) were infected with metacyclic parasites intravenously through the tail vein. Dosage: 2.5 mg/kg body weight per injection. Administration: Intraperitoneally every 2 days for 15 days (total, eight doses). Result: A drastic reduction of the number of transforming amastigotes recovered from the target organs of drug-treated animals was observed.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LMP-400 | NSC-724998

Quick Database Links

Gene Symbol

Topoisomerase