Indomethacin-d4 Methyl Ester

SKU: orb3138230

Description

Indomethacin-d4Methyl Ester is the deuterated form of Indomethacin. Indomethacin (Indometacin) serves as a potent, non-selective inhibitor of COX-1 and COX-2 that can cross the blood-brain barrier, with IC50 values of 18 nM for COX-1 and 26 nM for COX-2 in CHO cells. It disrupts autophagic flux by interfering with the normal function of lysosomes.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1217064-61-3
• MW: 375.84
• Formula: C₂₀H₁₈ClNO₄
• SMILES: C(=O)(N1C=2C(C(CC(OC)=O)=C1C)=CC(OC)=CC2)C3=C(C(=C(Cl)C(=C3[2H])[2H])[2H])[2H]
• Target: COX,Autophagy

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

COX,Autophagy