Indolelactic acid

SKU: orb1219648

Description

Indolelactic acid is a metabolite of tryptophan in Azotobacter vinelandii cultures.

Key Properties

• CAS Number: 1821-52-9
• MW: 205.21
• Purity: >98% (HPLC)
• Formula: C₁₁H₁₁NO₃
• SMILES: O=C(O)C(O)Cc2cnc1ccccc12
• Target: Endogenous Metabolite
• Solubility: DMSO:82 mg/mL (399.59mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Indolelactic acid (gavage feeding, 10 μM, 5 μL, 5 days, C57BL/6 mice) benefits the immature intestine preferentially. Animal model: C57BL/6 mice. Dosage: 10 μM, 5 μL. Administration: Gavage feeding, 5 days. Result: Upregulated the innate immune response genes in immature mouse intestine (C57-pup-ileum), with no effects on pup-colon or adult intestine.
• In Vitro:
  Indolelactic acid (1 mM, 5 days) upregulates CXCR3, granzyme B, and immunoregulatory galectin-1 in Th2 cells. Indolelactic acid (0.1-10 mM, 1 h) significantly inhibits LPS-induced inflammation in RAW blue macrophages and Caco-2 cells. Indolelactic acid (0.1-10 mM, 1 h) inhibits TNF-α induced inflammation in HT-29 cells. Indolelactic acid (10 mM, 1 h) activates the AhR and downstream Nrf2 pathway in Caco-2 cells. Indolelactic acid (5 μM, 24 h) enhances the IFIT2 and RSAD2 mRNA expression in H4 cells stimulated by IL-1β. RT-PCR Cell line: HT-29 cells. Concentration: 0.1, 1, 10 mM Incubation time: 1 h. Result: Decreased IL-8 level induced by TNF-α, and increased β-defensin 2 and SERT level.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Endogenous Metabolite