Incyclinide

SKU: orb1308198

Description

Incyclinide (CMT-3) is a non-antimicrobial tetracycline derivative that potently inhibits matrix metalloproteinases (MMPs). It has demonstrated efficacy in suppressing invasiveness and growth of various cancers, including prostate, colon, and melanoma, in both in vitro and in vivo experimental models.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 15866-90-7
• MW: 371.34
• Purity: 97.99% (May vary between batches)
• Formula: C₁₉H₁₇NO₇
• SMILES: [H][C@@]12Cc3cccc(O)c3C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)C[C@]1([H])C2
• Target: MMP
• Solubility: DMSO:95 mg/mL (255.83 mM)

Bioactivity

• In Vivo:
  Probably by reducing the number of osteoclasts at the compression side, Incyclinide suppresses tooth movement in the rat. Reduced MMP activity by incyclinide might also directly inhibit degradation of the organic bone matrix. This might be due to the induction of apoptosis in activated osteoclasts or reduced osteoclast migration .
• In Vitro:
  Incyclinide has been shown to experimentally suppress prostate cancer, colon adenocarcinoma, and melanoma invasiveness in cell culture. Adding incyclinide at final concentrations of 5 to 20 μM inhibits MT1-MMP gelatinolytic and caseinolytic activity, blocks MT1-MMPactivation of pro-MMP-2, and decreases invasiveness of HT-1080 fibrosarcoma cells . Most of the MICs of CMT-3 against filamentous fungi are found to be between 0.25 and 8 μg/mL, and the inhibition of viability of these fungi by incyclinide is routinely higher than 90% .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CMT 3, CMT3, CMT-3, COL 3, COL3, COL-3, Inhibitor, Matrix metalloproteinases, inhibit, MT1-MMP, Incyclinide, MMP

Compound Identifiers

PubChem CID

54678924